Pesquisa | BVS IEC

1.

Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors.

Xiong, Xiaozhe; Tian, Songhai; Yang, Pan; Lebreton, Francois; Bao, Huan; Sheng, Kuanwei; Yin, Linxiang; Chen, Pengsheng; Zhang, Jie; Qi, Wanshu; Ruan, Jianbin; Wu, Hao; Chen, Hong; Breault, David T; Wu, Hao; Earl, Ashlee M; Gilmore, Michael S; Abraham, Jonathan; Dong, Min.

Cell ; 185(7): 1157-1171.e22, 2022 03 31.

Artigo em Inglês | MEDLINE | ID: mdl-35259335

2.

A selective antibiotic for Lyme disease.

Leimer, Nadja; Wu, Xiaoqian; Imai, Yu; Morrissette, Madeleine; Pitt, Norman; Favre-Godal, Quentin; Iinishi, Akira; Jain, Samta; Caboni, Mariaelena; Leus, Inga V; Bonifay, Vincent; Niles, Samantha; Bargabos, Rachel; Ghiglieri, Meghan; Corsetti, Rachel; Krumpoch, Megan; Fox, Gabriel; Son, Sangkeun; Klepacki, Dorota; Polikanov, Yury S; Freliech, Cecily A; McCarthy, Julie E; Edmondson, Diane G; Norris, Steven J; D'Onofrio, Anthony; Hu, Linden T; Zgurskaya, Helen I; Lewis, Kim.

Cell ; 184(21): 5405-5418.e16, 2021 10 14.

Artigo em Inglês | MEDLINE | ID: mdl-34619078

3.

Genome-wide gene expression tuning reveals diverse vulnerabilities of M. tuberculosis.

Bosch, Barbara; DeJesus, Michael A; Poulton, Nicholas C; Zhang, Wenzhu; Engelhart, Curtis A; Zaveri, Anisha; Lavalette, Sophie; Ruecker, Nadine; Trujillo, Carolina; Wallach, Joshua B; Li, Shuqi; Ehrt, Sabine; Chait, Brian T; Schnappinger, Dirk; Rock, Jeremy M.

Cell ; 184(17): 4579-4592.e24, 2021 08 19.

Artigo em Inglês | MEDLINE | ID: mdl-34297925

4.

A Dual-Mechanism Antibiotic Kills Gram-Negative Bacteria and Avoids Drug Resistance.

Martin, James K; Sheehan, Joseph P; Bratton, Benjamin P; Moore, Gabriel M; Mateus, André; Li, Sophia Hsin-Jung; Kim, Hahn; Rabinowitz, Joshua D; Typas, Athanasios; Savitski, Mikhail M; Wilson, Maxwell Z; Gitai, Zemer.

Cell ; 181(7): 1518-1532.e14, 2020 06 25.

Artigo em Inglês | MEDLINE | ID: mdl-32497502

5.

Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.

Zhang, Bing; Li, Jun; Yang, Xiaolin; Wu, Lijie; Zhang, Jia; Yang, Yang; Zhao, Yao; Zhang, Lu; Yang, Xiuna; Yang, Xiaobao; Cheng, Xi; Liu, Zhijie; Jiang, Biao; Jiang, Hualiang; Guddat, Luke W; Yang, Haitao; Rao, Zihe.

Cell ; 176(3): 636-648.e13, 2019 01 24.

Artigo em Inglês | MEDLINE | ID: mdl-30682372

6.

A novel antibiotic class targeting the lipopolysaccharide transporter.

Zampaloni, Claudia; Mattei, Patrizio; Bleicher, Konrad; Winther, Lotte; Thäte, Claudia; Bucher, Christian; Adam, Jean-Michel; Alanine, Alexander; Amrein, Kurt E; Baidin, Vadim; Bieniossek, Christoph; Bissantz, Caterina; Boess, Franziska; Cantrill, Carina; Clairfeuille, Thomas; Dey, Fabian; Di Giorgio, Patrick; du Castel, Pauline; Dylus, David; Dzygiel, Pawel; Felici, Antonio; García-Alcalde, Fernando; Haldimann, Andreas; Leipner, Matthew; Leyn, Semen; Louvel, Séverine; Misson, Pauline; Osterman, Andrei; Pahil, Karanbir; Rigo, Sébastien; Schäublin, Adrian; Scharf, Sebastian; Schmitz, Petra; Stoll, Theodor; Trauner, Andrej; Zoffmann, Sannah; Kahne, Daniel; Young, John A T; Lobritz, Michael A; Bradley, Kenneth A.

Nature ; 625(7995): 566-571, 2024 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-38172634

7.

Discovery of a structural class of antibiotics with explainable deep learning.

Wong, Felix; Zheng, Erica J; Valeri, Jacqueline A; Donghia, Nina M; Anahtar, Melis N; Omori, Satotaka; Li, Alicia; Cubillos-Ruiz, Andres; Krishnan, Aarti; Jin, Wengong; Manson, Abigail L; Friedrichs, Jens; Helbig, Ralf; Hajian, Behnoush; Fiejtek, Dawid K; Wagner, Florence F; Soutter, Holly H; Earl, Ashlee M; Stokes, Jonathan M; Renner, Lars D; Collins, James J.

Nature ; 626(7997): 177-185, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38123686

8.

Mycobacterium abscessus HelR interacts with RNA polymerase to confer intrinsic rifamycin resistance.

Hurst-Hess, Kelley R; Saxena, Aavrati; Rudra, Paulami; Yang, Yong; Ghosh, Pallavi.

Mol Cell ; 82(17): 3166-3177.e5, 2022 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-35905736

9.

Unraveling the biology of a fungal meningitis pathogen using chemical genetics.

Brown, Jessica C S; Nelson, Justin; VanderSluis, Benjamin; Deshpande, Raamesh; Butts, Arielle; Kagan, Sarah; Polacheck, Itzhack; Krysan, Damian J; Myers, Chad L; Madhani, Hiten D.

Cell ; 159(5): 1168-1187, 2014 Nov 20.

Artigo em Inglês | MEDLINE | ID: mdl-25416953

10.

Porin-independent accumulation in Pseudomonas enables antibiotic discovery.

Geddes, Emily J; Gugger, Morgan K; Garcia, Alfredo; Chavez, Martin Garcia; Lee, Myung Ryul; Perlmutter, Sarah J; Bieniossek, Christoph; Guasch, Laura; Hergenrother, Paul J.

Nature ; 624(7990): 145-153, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-37993720

11.

Structural and mechanistic insights into fungal ß-1,3-glucan synthase FKS1.

Hu, Xinlin; Yang, Ping; Chai, Changdong; Liu, Jia; Sun, Huanhuan; Wu, Yanan; Zhang, Mingjie; Zhang, Min; Liu, Xiaotian; Yu, Hongjun.

Nature ; 616(7955): 190-198, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-36949198

12.

Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal.

Maji, Arun; Soutar, Corinne P; Zhang, Jiabao; Lewandowska, Agnieszka; Uno, Brice E; Yan, Su; Shelke, Yogesh; Murhade, Ganesh; Nimerovsky, Evgeny; Borcik, Collin G; Arango, Andres S; Lange, Justin D; Marin-Toledo, Jonnathan P; Lyu, Yinghuan; Bailey, Keith L; Roady, Patrick J; Holler, Jordan T; Khandelwal, Anuj; SantaMaria, Anna M; Sanchez, Hiram; Juvvadi, Praveen R; Johns, Gina; Hageman, Michael J; Krise, Joanna; Gebremariam, Teclegiorgis; Youssef, Eman G; Bartizal, Ken; Marr, Kieren A; Steinbach, William J; Ibrahim, Ashraf S; Patterson, Thomas F; Wiederhold, Nathan P; Andes, David R; Pogorelov, Taras V; Schwieters, Charles D; Fan, Timothy M; Rienstra, Chad M; Burke, Martin D.

Nature ; 623(7989): 1079-1085, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37938782

13.

Antibiotic combinations reduce Staphylococcus aureus clearance.

Lázár, Viktória; Snitser, Olga; Barkan, Daniel; Kishony, Roy.

Nature ; 610(7932): 540-546, 2022 10.

Artigo em Inglês | MEDLINE | ID: mdl-36198788

14.

A naturally inspired antibiotic to target multidrug-resistant pathogens.

Wang, Zongqiang; Koirala, Bimal; Hernandez, Yozen; Zimmerman, Matthew; Park, Steven; Perlin, David S; Brady, Sean F.

Nature ; 601(7894): 606-611, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34987225

15.

Teixobactin kills bacteria by a two-pronged attack on the cell envelope.

Shukla, Rhythm; Lavore, Francesca; Maity, Sourav; Derks, Maik G N; Jones, Chelsea R; Vermeulen, Bram J A; Melcrová, Adéla; Morris, Michael A; Becker, Lea Marie; Wang, Xiaoqi; Kumar, Raj; Medeiros-Silva, João; van Beekveld, Roy A M; Bonvin, Alexandre M J J; Lorent, Joseph H; Lelli, Moreno; Nowick, James S; MacGillavry, Harold D; Peoples, Aaron J; Spoering, Amy L; Ling, Losee L; Hughes, Dallas E; Roos, Wouter H; Breukink, Eefjan; Lewis, Kim; Weingarth, Markus.

Nature ; 608(7922): 390-396, 2022 08.

Artigo em Inglês | MEDLINE | ID: mdl-35922513

16.

Cefepime-Taniborbactam in Complicated Urinary Tract Infection.

Wagenlehner, Florian M; Gasink, Leanne B; McGovern, Paul C; Moeck, Greg; McLeroth, Patrick; Dorr, MaryBeth; Dane, Aaron; Henkel, Tim.

N Engl J Med ; 390(7): 611-622, 2024 Feb 15.

Artigo em Inglês | MEDLINE | ID: mdl-38354140

17.

IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance.

Singh, Kumar Sachin; Sharma, Rishabh; Reddy, Poli Adi Narayana; Vonteddu, Prashanthi; Good, Madeline; Sundarrajan, Anjana; Choi, Hyeree; Muthumani, Kar; Kossenkov, Andrew; Goldman, Aaron R; Tang, Hsin-Yao; Totrov, Maxim; Cassel, Joel; Murphy, Maureen E; Somasundaram, Rajasekharan; Herlyn, Meenhard; Salvino, Joseph M; Dotiwala, Farokh.

Nature ; 589(7843): 597-602, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-33361818

18.

A synthetic antibiotic class overcoming bacterial multidrug resistance.

Mitcheltree, Matthew J; Pisipati, Amarnath; Syroegin, Egor A; Silvestre, Katherine J; Klepacki, Dorota; Mason, Jeremy D; Terwilliger, Daniel W; Testolin, Giambattista; Pote, Aditya R; Wu, Kelvin J Y; Ladley, Richard Porter; Chatman, Kelly; Mankin, Alexander S; Polikanov, Yury S; Myers, Andrew G.

Nature ; 599(7885): 507-512, 2021 11.

Artigo em Inglês | MEDLINE | ID: mdl-34707295

19.

Antibiotic class with potent in vivo activity targeting lipopolysaccharide synthesis in Gram-negative bacteria.

Huseby, Douglas L; Cao, Sha; Zamaratski, Edouard; Sooriyaarachchi, Sanjeewani; Ahmad, Shabbir; Bergfors, Terese; Krasnova, Laura; Pelss, Juris; Ikaunieks, Martins; Loza, Einars; Katkevics, Martins; Bobileva, Olga; Cirule, Helena; Gukalova, Baiba; Grinberga, Solveiga; Backlund, Maria; Simoff, Ivailo; Leber, Anna T; Berruga-Fernández, Talía; Antonov, Dmitry; Konda, Vivekananda R; Lindström, Stefan; Olanders, Gustav; Brandt, Peter; Baranczewski, Pawel; Vingsbo Lundberg, Carina; Liepinsh, Edgars; Suna, Edgars; Jones, T Alwyn; Mowbray, Sherry L; Hughes, Diarmaid; Karlén, Anders.

Proc Natl Acad Sci U S A ; 121(15): e2317274121, 2024 Apr 09.

Artigo em Inglês | MEDLINE | ID: mdl-38579010

20.

Theoretical considerations and empirical predictions of the pharmaco- and population dynamics of heteroresistance.

Levin, Bruce R; Berryhill, Brandon A; Gil-Gil, Teresa; Manuel, Joshua A; Smith, Andrew P; Choby, Jacob E; Andersson, Dan I; Weiss, David S; Baquero, Fernando.

Proc Natl Acad Sci U S A ; 121(16): e2318600121, 2024 Apr 16.

Artigo em Inglês | MEDLINE | ID: mdl-38588431

BVS IEC

Instituto Evandro Chagas

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